Open AccessAdvances in single‐cell sequencing and its application to musculoskeletal system research
Author(s) -
Zhang Yongxiang,
Wang Jingkai,
Yu Chao,
Xia Kaishun,
Yang Biao,
Zhang Yuang,
Ying Liwei,
Wang Chenggui,
Huang Xianpeng,
Chen Qixin,
Shen Li,
Li Fangcai,
Liang Chengzhen
Publication year - 2022
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.13161
Subject(s) - emerging technologies , computer science , risk analysis (engineering) , data science , medicine , artificial intelligence
In recent years, single‐cell sequencing (SCS) technologies have continued to advance with improved operating procedures and reduced cost, leading to increasing practical adoption among researchers. These emerging technologies have superior abilities to analyse cell heterogeneity at a single‐cell level, which have elevated multi‐omics research to a higher level. In some fields of research, application of SCS has enabled many valuable discoveries, and musculoskeletal system offers typical examples. This article reviews some major scientific issues and recent advances in musculoskeletal system. In addition, combined with SCS technologies, the research of cell or tissue heterogeneity in limb development and various musculoskeletal system clinical diseases also provides new possibilities for treatment strategies. Finally, this article discusses the challenges and future development potential of SCS and recommends the direction of future applications of SCS to musculoskeletal medicine.