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Human mesenchymal stem cells
Author(s) -
Chen Xiaoyong,
Huang Jing,
Wu Jun,
Hao Jie,
Fu Boqiang,
Wang Ying,
Zhou Bo,
Na Tao,
Wei Jun,
Zhang Yong,
Li Qiyuan,
Hu Shijun,
Zhou Jiaxi,
Yu Junying,
Wu Zhaohui,
Zhu Huanxin,
Cao Jiani,
Wang Lei,
Peng Yaojin,
Liang Lingmin,
Ma Aijin,
Zhang Yu,
Zhao Tongbiao,
Xiang Andy Peng
Publication year - 2022
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.13141
Subject(s) - mesenchymal stem cell , standardization , stem cell , regenerative medicine , regeneration (biology) , computer science , cell therapy , risk analysis (engineering) , microbiology and biotechnology , business , biology , operating system
Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self‐renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources or each individual have great differences in their transcriptomic signatures, differentiation potential and biological functions. Therefore, there is an urgent need for consensus standard for the quality control and technical specifications of MSCs. ‘Human Mesenchymal Stem Cells’ is the latest set of guidelines on hMSC in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for hMSC, which is applicable to the quality control for hMSC. It was originally released by the China Society for Cell Biology on 9 January 2021. We hope that publication of these guidelines will facilitate institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of hMSC for clinical development and therapeutic applications.

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