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open-access-imgOpen AccessRole of CXCR4 in the progression and therapy of acute leukaemia
Su Long,
Hu Zheng,
Yang YongGuang
Publication year2021
Publication title
cell proliferation
Resource typeJournals
Abstract CXCR4 is expressed on leukaemia cells and haematopoietic stem cells (HSCs), and its ligand stromal‐derived factor 1 (SDF‐1) is produced abundantly by stromal cells in the bone marrow (BM). The SDF‐1/CXCR4 axis plays important roles in homing to and retention in the protective BM microenvironment of malignant leukaemia cells and normal HSCs. CXCR4 expression is regulated by multiple mechanisms and the level of CXCR4 expression on leukaemia cells has prognostic indications in patients with acute leukaemia. CXCR4 antagonists can mobilize leukaemia cells from BM to circulation, which render them effectively eradicated by chemotherapeutic agents, small molecular inhibitors or hypomethylating agents. Therefore, such combinational therapies have been tested in clinical trials. However, new evidence emerged that drug‐resistant leukaemia cells were not affected by CXCR4 antagonists, and the migration of certain leukaemia cells to the leukaemia niche was independent of SDF‐1/CXCR4 axis. In this review, we summarize the role of CXCR4 in progression and treatment of acute leukaemia, with a focus on the potential of CXCR4 as a therapeutic target for acute leukaemia. We also discuss the potential value of using CXCR4 antagonists as chemosensitizer for conditioning regimens and immunosensitizer for graft‐vs‐leukaemia effects of allogeneic haematopoietic stem cell transplantation.
Subject(s)biology , bone marrow , cancer research , chemokine , cxcr4 , ecology , haematopoiesis , homing (biology) , immune system , immunology , medicine , microbiology and biotechnology , stem cell , stromal cell
Keyword(s) CXCR4 , acute myeloid leukaemia , acute lymphoblastic leukaemia , haematopoietic stem cell transplantation
SCImago Journal Rank1.647

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