Open AccessSterol metabolism and protein metabolism are differentially correlated with sarcopenia in Asian Chinese men and women
Author(s) -
Li ChunWei,
Yu Kang,
ShyhChang Ng,
Li GuoXun,
Yu SongLin,
Liu HuiJun,
Yang Bo,
Li ZiYao,
Zhao YongJie,
Xu LongYu,
Xu Jing,
Jiang LingJuan,
Liu RongJi,
Zhang XinYuan,
Li ShaoFei,
Zhang XiaoWei,
Xie HaiYan,
Li Kang,
Zhan YiXiang,
Cui Min,
Tao HangBo,
Li Yao,
Liu GaoShan,
Ni KeMin,
Li DongJing
Publication year - 2021
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12989
Subject(s) - sarcopenia , medicine , logistic regression , sarcopenic obesity , body mass index , prospective cohort study , gerontology , odds ratio , endocrinology
Objectives Our aim was to investigate the prevalence and predictive variables of sarcopenia. Methods We recruited participants from the Peking Union Medical College Hospital Multicenter Prospective Longitudinal Sarcopenia Study (PPLSS). Muscle mass was quantified using bioimpedance, and muscle function was quantified using grip strength and gait speed. Logistic regression revealed the relationships between sarcopenia and nutritional, lifestyle, disease, psychosocial and physical variables. Results The prevalence of sarcopenia and sarcopenic obesity was 9.2%‐16.2% and 0.26%‐9.1%, respectively. Old age, single status, undernourishment, higher income, smoking, low physical activity, poor appetite and low protein diets were significantly associated with sarcopenia. Multiple logistic regression analysis showed that age was a risk factor for all stages of sarcopenia, and participants above 80 years were greater than fivefold more susceptible to sarcopenia, while lower physical activity was an independent risk factor. The optimal cut‐off value for age was 71 years, which departs from the commonly accepted cut‐off of 60 years. Female participants were greater than twofold less susceptible to sarcopenia than male participants. The sterol derivative 25‐hydroxyvitamin D was associated with fourfold lower odds of sarcopenia in male participants. Several protein intake variables were also correlated with sarcopenia. Based on these parameters, we defined a highly predictive index for sarcopenia. Conclusions Our findings support a predictive index of sarcopenia, which agglomerates the complex influences that sterol metabolism and nutrition exert on male vs female participants.