Open AccessSuper enhancers—Functional cores under the 3D genome
Author(s) -
Zhang Juqing,
Yue Wei,
Zhou Yaqi,
Liao Mingzhi,
Chen Xingqi,
Hua Jinlian
Publication year - 2021
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12970
Subject(s) - enhancer , chromatin , biology , genome , computational biology , enhancer rnas , transcription (linguistics) , human genome , gene , regulation of gene expression , transcriptional regulation , transcription factor , genetics , microbiology and biotechnology , linguistics , philosophy
Complex biochemical reactions take place in the nucleus all the time. Transcription machines must follow the rules. The chromatin state, especially the three‐dimensional structure of the genome, plays an important role in gene regulation and expression. The super enhancers are important for defining cell identity in mammalian developmental processes and human diseases. It has been shown that the major components of transcriptional activation complexes are recruited by super enhancer to form phase‐separated condensates. We summarize the current knowledge about super enhancer in the 3D genome. Furthermore, a new related transcriptional regulation model from super enhancer is outlined to explain its role in the mammalian cell progress.