Open AccessPotential role of insulin on the pathogenesis of depression
Author(s) -
Zou Xiao Han,
Sun Li Hua,
Yang Wei,
Li Bing Jin,
Cui Ran Ji
Publication year - 2020
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12806
Subject(s) - depression (economics) , insulin , pathogenesis , neuroprotection , insulin receptor , neurotrophin , affect (linguistics) , medicine , neurotrophic factors , neuroscience , endocrinology , psychology , receptor , insulin resistance , communication , economics , macroeconomics
The regulation of insulin on depression and depression‐like behaviour has been widely reported. Insulin and activation of its receptor can promote learning and memory, affect the hypothalamic‐pituitary‐adrenal axis (HPA) balance, regulate the secretion of neurotrophic factors and neurotransmitters, interact with gastrointestinal microbiome, exert neuroprotective effects and have an impact on depression. However, the role of insulin on depression remains largely unclear. Therefore, in this review, we summarized the potential role of insulin on depression. It may provide new insight for clarifying role of insulin on the pathogenesis of depression.