Open AccessThe role of astrocytes in oxidative stress of central nervous system: A mixed blessing
Author(s) -
Chen Yaxing,
Qin Chen,
Huang Jianhan,
Tang Xin,
Liu Chang,
Huang Keru,
Xu Jianguo,
Guo Gang,
Tong Aiping,
Zhou Liangxue
Publication year - 2020
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12781
Subject(s) - oxidative stress , central nervous system , neuroscience , homeostasis , astrocyte , biology , function (biology) , microbiology and biotechnology , endocrinology
Central nervous system (CNS) maintains a high level of metabolism, which leads to the generation of large amounts of free radicals, and it is also one of the most vulnerable organs to oxidative stress. Emerging evidences have shown that, as the key homeostatic cells in CNS, astrocytes are deeply involved in multiple aspects of CNS function including oxidative stress regulation. Besides, the redox level in CNS can in turn affect astrocytes in morphology and function. The complex and multiple roles of astrocytes indicate that their correct performance is crucial for the normal functioning of the CNS, and its dysfunction may result in the occurrence and progression of various neurological disorders. To date, the influence of astrocytes in CNS oxidative stress is rarely reviewed. Therefore, in this review we sum up the roles of astrocytes in redox regulation and the corresponding mechanisms under both normal and different pathological conditions.