Open AccessThe role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer
Author(s) -
Xu Yichi,
Zou Ruanmin,
Wang Jing,
Wang Zhiwei,
Zhu Xueqiong
Publication year - 2020
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12770
Subject(s) - immunotherapy , cancer , carcinogenesis , metastasis , cancer immunotherapy , cancer research , melanoma , antigen , immunology , biology , medicine
Preferentially expressed antigen in melanoma (PRAME), which belongs to the cancer/testis antigen (CTA) gene family, plays a pivotal role in multiple cellular processes and immunotherapy response in human cancers. PRAME is highly expressed in different types of cancers and is involved in cell proliferation, apoptosis, differentiation and metastasis as well as the outcomes of patients with cancer. In this review article, we discuss the potential roles and physiological functions of PRAME in various types of cancers. Moreover, this review highlights immunotherapeutic strategies that target PRAME in human malignancies. Therefore, the modulation of PRAME might be useful for the treatment of patients with cancer.