Open AccessEmerging roles of non‐coding RNAs in scoliosis
Author(s) -
Li Zheng,
Li Xingye,
Shen Jianxiong,
Zhang Lin,
Chan Matthew T. V.,
Wu William K. K.
Publication year - 2020
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12736
Subject(s) - scoliosis , circular rna , microrna , non coding rna , biology , bioinformatics , computational biology , rna , pathogenesis , deformity , genetics , gene , medicine , immunology
Scoliosis, a complex three‐dimensional deformity of the spine with the Cobb angle (a measure of the spinal lateral curvature) >10 degree, encompasses a spectrum of pathologies, including congenital, idiopathic, syndromic and neuromuscular aetiologies. The pathogenesis is multifactorial involving both environmental and genetic factors but the exact cellular and molecular mechanisms of disease development remain largely unknown. Emerging evidence showed that non‐coding RNAs (ncRNAs), namely microRNAs, long ncRNAs and circular RNAs, are deregulated in many orthopaedic diseases, including scoliosis. Importantly, these deregulated ncRNAs functionally participate in the initiation and progression of scoliosis. Here, we review recent progress in ncRNA research on scoliosis.