Open AccessDeciphering role of FGFR signalling pathway in pancreatic cancer
Author(s) -
Kang Xiaodiao,
Lin Zeng,
Xu Minhui,
Pan Jun,
Wang Zhiwei
Publication year - 2019
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12605
Subject(s) - pancreatic cancer , angiogenesis , metastasis , fibroblast growth factor , cancer research , fibroblast growth factor receptor , cancer , signal transduction , carcinogenesis , biology , signalling pathways , microbiology and biotechnology , receptor , biochemistry , genetics
Recently, fibroblast growth factors are identified to play a vital role in the development and progression of human pancreatic cancer. FGF pathway is critical involved in numerous cellular processes through regulation of its downstream targets, including proliferation, apoptosis, migration, invasion, angiogenesis and metastasis. In this review article, we describe recent advances of FGFR signalling pathway in pancreatic carcinogenesis and progression. Moreover, we highlight the available chemical inhibitors of FGFR pathway for potential treatment of pancreatic cancer. Furthermore, we discuss whether targeting FGFR pathway is a novel therapeutic strategy for pancreatic cancer clinical management.