Deciphering role of FGFR signalling pathway in pancreatic cancer | Zendy

Kang Xiaodiao | Zendy; Lin Zeng | Zendy; Xu Minhui | Zendy; Pan Jun | Zendy; Wang Zhiwei | Zendy

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Deciphering role of FGFR signalling pathway in pancreatic cancer

Author(s) -

Kang Xiaodiao,

Lin Zeng,

Xu Minhui,

Pan Jun,

Wang Zhiwei

Publication year - 2019

Publication title -

cell proliferation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.647

H-Index - 74

eISSN - 1365-2184

pISSN - 0960-7722

DOI - 10.1111/cpr.12605

Subject(s) - pancreatic cancer , signalling , signalling pathways , biology , fibroblast growth factor receptor , microbiology and biotechnology , cancer , cancer research , signal transduction , fibroblast growth factor , receptor , genetics

Recently, fibroblast growth factors are identified to play a vital role in the development and progression of human pancreatic cancer. FGF pathway is critical involved in numerous cellular processes through regulation of its downstream targets, including proliferation, apoptosis, migration, invasion, angiogenesis and metastasis. In this review article, we describe recent advances of FGFR signalling pathway in pancreatic carcinogenesis and progression. Moreover, we highlight the available chemical inhibitors of FGFR pathway for potential treatment of pancreatic cancer. Furthermore, we discuss whether targeting FGFR pathway is a novel therapeutic strategy for pancreatic cancer clinical management.

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