Open AccessEmerging roles of long non‐coding RNAs in neuropathic pain
Author(s) -
Li Zheng,
Li Xingye,
Chen Xin,
Li Shugang,
Ho Idy H. T.,
Liu Xiaodong,
Chan Matthew T. V.,
Wu William K. K.
Publication year - 2019
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12528
Subject(s) - neuropathic pain , chronic pain , neuroscience , medicine , disease , long non coding rna , nervous system , bioinformatics , spinal cord injury , spinal cord , biology , gene , rna , pathology , genetics
Neuropathic pain, a type of chronic and potentially disabling pain resulting from primary injury/dysfunction of the somatosensory nervous system and spinal cord injury, is one of the most intense types of chronic pain, which incurs a significant economic and public health burden. However, our understanding of its cellular and molecular pathogenesis is still far from complete. Long non‐coding RNAs (lncRNAs) are important regulators of gene expression and have recently been characterized as key modulators of neuronal functions. Emerging evidence suggested that lncRNAs are deregulated and play pivotal roles in the development of neuropathic pain. This review summarizes the current knowledge about the roles of deregulated lncRNAs (eg, KCNA2‐AS, uc.48+, NONRATT021972, MRAK009713, XIST, CCAT1) in the development of neuropathic pain. These studies suggested that specific regulation of lncRNAs or their downstream targets might provide novel therapeutic avenues for this refractory disease.