Open AccessZFAS 1: A novel vital oncogenic lnc RNA in multiple human cancers
Author(s) -
He Anbang,
He Shiming,
Li Xuesong,
Zhou Liqun
Publication year - 2019
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12513
Subject(s) - rna , biology , antisense rna , long non coding rna , epigenetics , non coding rna , rna polymerase ii , oncogene , translation (biology) , gene expression , zinc finger , cancer , cancer research , gene , messenger rna , genetics , promoter , cell cycle , transcription factor
Long noncoding RNA s (lnc RNA s) are a class of noncoding, endogenous, single‐stranded RNA s longer than 200 nucleotides in length that are transcribed by RNA polymerase II . Mounting evidence has indicated that lnc RNA s play key roles in several physiological and pathological processes by modifying gene expression at the transcriptional, posttranscriptional, epigenetic, and translation levels. Many reports have demonstrated that lnc RNA s function as potential oncogene or tumour suppressors and thus play vital regulatory roles in tumourigenesis and tumour progression. ZNFX 1 antisense RNA 1 ( ZFAS 1), a novel lnc RNA transcribed in the antisense orientation of zinc finger NFX 1‐type containing 1( ZNFX 1), was found to be increased in multiple cancers, such as gastric cancer and hepatocellular carcinoma, contributing to cancer development and progression. In the present review, we summarized recent progression on study of the functions and underlying molecular mechanisms of ZFAS 1 related to occurrence and development of multiple cancers.