Open AccessCRNDE : An important oncogenic long non‐coding RNA in human cancers
Author(s) -
Zhang Jiaming,
Yin Minuo,
Peng Gang,
Zhao Yingchao
Publication year - 2018
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12440
Subject(s) - long non coding rna , rna , cancer research , biology , cell growth , apoptosis , coding (social sciences) , gene , genetics , statistics , mathematics
Aberrant overexpression of long non‐coding RNA CRNDE (Colorectal Neoplasia Differentially Expressed) is confirmed in various human cancers, which is correlated with advanced clinicopathological features and poor prognosis. CRNDE promotes cancer cell proliferation, migration and invasion, and suppresses apoptosis in complicated mechanisms, which result in the initialization and development of human cancers. In this review, we provide an overview of the oncogenic role and potential clinical applications of CRNDE .