Open AccessFinasteride accelerates prostate wound healing after thulium laser resection through DHT and AR signalling
Author(s) -
Zhao Ruizhe,
Wang Xingjie,
Jiang Chenyi,
Shi Fei,
Zhu Yiping,
Yang Boyu,
Zhuo Jian,
Jing Yifeng,
Luo Guangheng,
Xia Shujie,
Han Bangmin
Publication year - 2018
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12415
Subject(s) - finasteride , prostate , urology , medicine , dihydrotestosterone , lower urinary tract symptoms , testosterone (patch) , urethra , prostatic urethra , transurethral resection of the prostate , androgen , andrology , hormone , cancer
Objectives Urinary tract infection, urinary frequency, urgency, urodynia and haemorrhage are common post‐operative complications of thulium laser resection of the prostate (Tm LRP ). Our study mainly focuses on the role of finasteride in prostate wound healing through AR signalling. Materials and methods Tm LRP beagles were randomly distributed into different treatment groups. Serum and intra‐prostatic testosterone and DHT level were determined. Histological analysis was conducted to study the re‐epithelialization and inflammatory response of the prostatic urethra in each group. We investigated the role of androgen in proliferation and inflammatory response in prostate. In addition, the effects of TNF ‐α on prostate epithelium and stromal cells were also investigated. Results Testosterone and DHT level increased in testosterone group and DHT decreased in finasteride group. Accelerated wound healing of prostatic urethra was observed in the finasteride group. DHT suppressed proliferation of prostate epithelium and enhanced inflammatory response in prostate. We confirmed that DHT enhanced macrophages TNF ‐α secretion through AR signalling. TNF ‐α suppressed proliferation of prostate epithelial cells and retarded cell migration. TNF ‐α also played a pivotal role in suppressing fibroblasts activation and contraction. Conclusion Testosterone treatment repressed re‐epithelialization and wound healing of prostatic urethra. Finasteride treatment may be an effective way to promote prostate re‐epithelialization.