Open AccessLong non‐coding RNA s in rheumatoid arthritis
Author(s) -
Li Zheng,
Li Xingye,
Jiang Chao,
Qian Wenwei,
Tse Gary,
Chan Matthew T.V.,
Wu William K.K.
Publication year - 2018
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12404
Subject(s) - rheumatoid arthritis , rna , immune system , autoimmunity , immunology , long non coding rna , medicine , autoimmune disease , arthritis , inflammation , gene expression , biology , gene , cancer research , genetics , antibody
Abstract Rheumatoid arthritis, a disabling autoimmune disease, is associated with altered gene expression in circulating immune cells and synovial tissues. Accumulating evidence has suggested that long non‐coding RNA s (lnc RNA s), which modulate gene expression through multiple mechanisms, are important molecules involved in immune and inflammatory pathways. Importantly, many studies have reported that lnc RNA s can be utilized as biomarkers for disease diagnosis and prognostication. Recently, dysregulation of lnc RNA s in rheumatoid arthritis and other autoimmune diseases has been revealed. Experimental studies also confirmed their crosstalk with matrix metalloproteinases, nuclear factor‐κB signalling and T‐cell response pertinent to autoimmunity and inflammation. Circulating lnc RNA s, such as HOTAIR , differentiated patients with rheumatoid arthritis from healthy subjects. Taken together, lnc RNA s are good candidates as biomarkers and therapeutic targets in rheumatoid arthritis. Further investigation on in vivo delivery of these regulatory molecules and large‐cohort validation of their clinical applicability may be useful.