Open AccessStem cell‐derived exosomes: A promising strategy for fracture healing
Author(s) -
Hao ZiChen,
Lu Jun,
Wang ShanZheng,
Wu Hao,
Zhang YunTong,
Xu ShuoGui
Publication year - 2017
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12359
Subject(s) - microvesicles , bone healing , stem cell , exosome , angiogenesis , regeneration (biology) , medicine , bioinformatics , microbiology and biotechnology , biology , cancer research , microrna , surgery , biochemistry , gene
Objectives To describe the biological characteristics of exosomes and to summarize the current status of stem cell‐derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed. Methods Search and analyze the related articles in pubmed database through the multi‐combination of keywords like “stem cells”,”exosomes”,”bone regeneration” and “fracture healing”. Conclusion Stem cell‐derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention. This strategy helps to promote proliferation and migration of cells, as well as osteogenesis and angiogenesis, in the process of bone formation. Although the exact mechanisms remain elusive, exosomal mi RNA s seem to play vital roles. Future studies are required to solve multiple problems before clinical application, including comprehensive and thorough understanding of exosomes, the exact roles of exosomes in regulating bone formation, and the optimal source, dose and frequency of treatment, as well as technical and safety issues. Moreover, studies based on fracture models of large animals are could offer guidance and are in demand.