CCAT 2: A novel oncogenic long non‐coding RNA in human cancers

Colon cancer‐associated transcript 2 ( CCAT 2) was originally identified as an oncogenic long non‐coding RNA in colorectal cancer. Since its discovery, the oncogenic role of CCAT 2 has been increasingly demonstrated in human cancers. In this connection, CCAT 2 upregulation is frequently reported and very often associated with tumour progression and poor clinical outcomes. Functionally, knockdown of CCAT 2 could induce cancer cell apoptosis and suppress cell proliferation and invasiveness, suggesting that CCAT 2 might be a therapeutic target. The present review summarized current literature concerning the expression and functional role of CCAT 2 in human malignancies.