Open AccessCCAT 2: A novel oncogenic long non‐coding RNA in human cancers
Author(s) -
Xin Yu,
Li Zheng,
Zheng Heyi,
Chan Matthew T.V.,
Ka Kei Wu William
Publication year - 2017
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12342
Subject(s) - downregulation and upregulation , long non coding rna , biology , gene knockdown , cancer research , rna , cell growth , cancer , colorectal cancer , apoptosis , antisense rna , gene , genetics
Colon cancer‐associated transcript 2 ( CCAT 2) was originally identified as an oncogenic long non‐coding RNA in colorectal cancer. Since its discovery, the oncogenic role of CCAT 2 has been increasingly demonstrated in human cancers. In this connection, CCAT 2 upregulation is frequently reported and very often associated with tumour progression and poor clinical outcomes. Functionally, knockdown of CCAT 2 could induce cancer cell apoptosis and suppress cell proliferation and invasiveness, suggesting that CCAT 2 might be a therapeutic target. The present review summarized current literature concerning the expression and functional role of CCAT 2 in human malignancies.