Open AccessLipopolysaccharide induced vascular smooth muscle cells proliferation: A new potential therapeutic target for proliferative vascular diseases
Author(s) -
Jiang Dehua,
Yang Yu,
Li Dongye
Publication year - 2017
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12332
Subject(s) - vascular smooth muscle , restenosis , lipopolysaccharide , signalling pathways , microbiology and biotechnology , cell growth , smooth muscle , signal transduction , receptor , biology , immunology , medicine , endocrinology , biochemistry , stent
Vascular smooth muscle cells ( VSMC s) proliferation is involved in vascular atherosclerosis and restenosis. Recent studies have demonstrated that lipopolysaccharide ( LPS ) promotes VSMC s proliferation, but the signalling pathways which are involved are not completely understood. The purpose of this review was to summarize the existing knowledge of the role and molecular mechanisms involved in controlling VSMC s proliferation stimulated by LPS and mediated by toll‐like receptor 4 ( TLR 4) signalling pathways. Moreover, the potential inhibitors of TLR 4 signalling for VSMC s proliferation in proliferative vascular diseases are discussed.