Open AccessNEAT 1: A novel cancer‐related long non‐coding RNA
Author(s) -
Yu Xin,
Li Zheng,
Zheng Heyi,
Chan Matthew T. V.,
Wu William Ka Kei
Publication year - 2017
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12329
Subject(s) - long non coding rna , rna , cancer research , lung cancer , messenger rna , cancer , biology , hepatocellular carcinoma , medicine , chemistry , immunology , gene , genetics
Aberrant overexpression of the long non‐coding RNA NEAT 1 (nuclear paraspeckle assembly transcript 1) has been documented in different types of solid tumours, such as lung cancer, oesophageal cancer, colorectal cancer and hepatocellular carcinoma, in which its high levels are associated with poor prognosis. In contrast, NEAT 1 is downregulated in acute promyelocytic leukaemia where it promotes leucocyte differentiation. In this review, we provide an overview of current evidence concerning the oncogenic role and potential clinical utilities of NEAT 1. Further investigations are warranted to elucidate the upstream and downstream mechanisms of NEAT 1 overexpression.