Open AccessRole of AhR in positive regulation of cell proliferation and survival
Author(s) -
Yin Jiuheng,
Sheng Baifa,
Qiu Yuan,
Yang Kunqiu,
Xiao Weidong,
Yang Hua
Publication year - 2016
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12282
Subject(s) - aryl hydrocarbon receptor , cell growth , transcription factor , cyp1b1 , biology , microbiology and biotechnology , cell cycle , apoptosis , cytokine , receptor , cell , cancer research , immunology , metabolism , endocrinology , cytochrome p450 , biochemistry , gene
The aryl hydrocarbon receptor (AhR) is an important nuclear transcription factor that is best known for mediating toxic responses by adjusting numbers of metabolism‐related enzymes, including CYP 1A1 and CYP 1B1. Previous findings have revealed that, in addition to negatively regulating cell proliferation and survival, AhR may also positively regulate these pathways. Here, we review these findings and summarize distinct mechanisms by which AhR promotes cell proliferation and survival, including modulation of receptor expression, growth factor signalling and apoptosis, regulating the cell cycle and promoting cytokine expression. This review will aid better understanding the role of AhR in positive regulation of cell proliferation and survival.