Open AccessTUG 1: a pivotal oncogenic long non‐coding RNA of human cancers
Author(s) -
Li Zheng,
Shen Jianxiong,
Chan Matthew T.V.,
Wu William Ka Kei
Publication year - 2016
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12269
Subject(s) - rna , biology , cancer research , long non coding rna , cell growth , osteosarcoma , downregulation and upregulation , cancer , cell , non coding rna , gene , genetics
Long non‐coding RNA s (lnc RNA s) are a group greater than 200 nucleotides in length. An increasing number of studies has shown that lnc RNA s play important roles in diverse cellular processes, including proliferation, differentiation, apoptosis, invasion and chromatin remodelling. In this regard, deregulation of lnc RNA s has been documented in human cancers. TUG 1 is a recently identified oncogenic lnc RNA whose aberrant upregulation has been detected in different types of cancer, including B‐cell malignancies, oesophageal squamous cell carcinoma, bladder cancer, hepatocellular carcinoma and osteosarcoma. In these malignancies, knock‐down of TUG 1 has been shown to suppress cell proliferation, invasion and/or colony formation. Interestingly, TUG 1 has been found to be downregulated in non‐small cell lung carcinoma, indicative of its tissue‐specific function in tumourigenesis. Pertinent to clinical practice, TUG 1 may act as a prognostic biomarker for tumours. In this review, we summarize current knowledge concerning the role of TUG 1 in tumour progression and discuss mechanisms associated with it.