Open AccessMicro RNA dysregulation in rhabdomyosarcoma: a new player enters the game
Author(s) -
Li Zheng,
Yu Xin,
Shen Jianxiong,
Liu Yang,
Chan Matthew T. V.,
Wu William K. K.
Publication year - 2015
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12199
Subject(s) - rna , rhabdomyosarcoma , messenger rna , malignancy , gene expression , metastasis , biology , cancer research , gene , bioinformatics , medicine , computational biology , genetics , sarcoma , pathology , cancer
Rhabdomyosarcoma ( RMS ) is the most common of the soft tissue sarcomas with resultant high morbidity, frequently occuring in paediatric patients and young adults. While the molecular basis of RMS has received considerable attention, exact mechanisms underlying its development and metastasis remain unclear. Micro RNA s (mi RNA s) are endogenously expressed small non‐coding RNA s that negatively regulate gene expression via translational inhibition or mRNA degradation. Deregulated expression of mi RNA has been implicated in initiation, progression, and metastasis of RMS . mi RNA s have emerged as key regulators of several physiological and pathophysiological processes and have opened new avenues for diagnosis and treatment of RMS . This review summarizes deregulation and functional roles of mi RNA s in RMS and their potential applications for diagnosis, prognosis and treatment of this malignancy. As a rapidly evolving field in basic and translational medicine, it is hopeful that mi RNA research will ultimately improve management of RMS .