Open AccessMi RNA s in primary cutaneous lymphomas
Author(s) -
Yu Xin,
Li Zheng,
Liu Jie
Publication year - 2015
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12179
Subject(s) - rna , gene expression , microrna , carcinogenesis , cancer research , biology , non coding rna , disease , messenger rna , pathogenesis , gene , computational biology , medicine , genetics , immunology , pathology
Abstract Primary cutaneous lymphomas ( PCL ) compose a heterogeneous disease with still unknown aetiology and mechanisms of development. Micro RNA s (mi RNA s) have recently been discovered as one of the crucial players in PCL carcinogenesis through post‐transcriptional regulation of gene expression. mi RNA s have been reported to be frequently deregulated in PCL s and their biological significance has been further confirmed in multiple functional experiments. Such studies help us understand molecular pathogenesis of PCL . In this review, we summarize expression of mi RNA s and their corresponding roles in different subtypes of PCL . With expression and functional role of mi RNA s revealed, investigation of their possible clinical use as biomarkers for diagnosis, prediction of prognosis and target for therapies, will be a promising area in the future.