Mi RNA s in primary cutaneous lymphomas

Primary cutaneous lymphomas ( PCL ) compose a heterogeneous disease with still unknown aetiology and mechanisms of development. Micro RNA s (mi RNA s) have recently been discovered as one of the crucial players in PCL carcinogenesis through post‐transcriptional regulation of gene expression. mi RNA s have been reported to be frequently deregulated in PCL s and their biological significance has been further confirmed in multiple functional experiments. Such studies help us understand molecular pathogenesis of PCL . In this review, we summarize expression of mi RNA s and their corresponding roles in different subtypes of PCL . With expression and functional role of mi RNA s revealed, investigation of their possible clinical use as biomarkers for diagnosis, prediction of prognosis and target for therapies, will be a promising area in the future.