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Physiological measures in participants with chronic fatigue syndrome, multiple sclerosis and healthy controls following repeated exercise: a pilot study
Author(s) -
Hodges L. D.,
Nielsen T.,
Baken D.
Publication year - 2018
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/cpf.12460
Subject(s) - medicine , chronic fatigue syndrome , heart rate , rating of perceived exertion , anaerobic exercise , repeated measures design , physical therapy , multiple sclerosis , cardiology , blood pressure , immunology , statistics , mathematics
Summary Purpose To compare physiological responses of chronic fatigue syndrome ( CFS / ME ), multiple sclerosis ( MS ) and healthy controls ( HC ) following a 24‐h repeated exercise test. Methods Ten CFS , seven MS and 17 age‐ and gender‐matched healthy controls (10, CFS HC ; and seven, MS HC ) were recruited. Each participant completed a maximal incremental cycle exercise test on day 1 and again 24 h later. Heart rate ( HR ), blood pressure ( BP ), rating of perceived exertion ( RPE ), oxygen consumption ( V ˙ O 2 ), carbon dioxide production and workload ( WL ) were recorded. Data analysis investigated these responses at anaerobic threshold ( AT ) and peak work rate ( PWR ). Results On day 2, both CFS and MS had significantly reduced max workload compared to HC . On day 2, significant differences were apparent in WL between CFS and CFS HC (93 ± 37 W, 132 ± 42 W, P <0·042). CFS workload decreased on day 2, alongside a decrease in HR but with an increase inV ˙ O 2(ml kg min −1 ). This was in comparison with an increase in WL , HR andV ˙ O 2for CFS HC . MS demonstrated a decreased WL compared to MS HC on both days of the study (D1 81 ± 30 W, 116 ±30 W; D2 84 ± 29 W, 118 ± 36 W); however, patients with MS were able to achieve a higher WL on day 2 alongside MS HC . Conclusion These results suggest that exercise exhibits a different physiological response in MS and CFS / ME , demonstrating repeated cardiovascular exercise testing as a valid measure for differentiating between fatigue conditions.