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Intra‐ and interday reproducibility of high‐flow‐mediated constriction response in young adults
Author(s) -
Ostrem Joseph D.,
Evanoff Nicholas G.,
Ryder Justin R.,
Dengel Donald R.
Publication year - 2018
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/cpf.12399
Subject(s) - reproducibility , medicine , brachial artery , constriction , forearm , nuclear medicine , occlusion , cardiology , surgery , statistics , mathematics , blood pressure
Summary Background Previously, we have demonstrated that high‐flow‐mediated constriction (H‐ FMC ) of the brachial artery has been shown to negatively affect flow‐mediated dilation ( FMD ). However, the reproducibility of an H‐ FMC response is unknown. Objective The aim of this study was to determine the intra‐ and interday reproducibility of H‐ FMC in young adults. Methods Thirty young adults (15 male, 15 female; 24 ± 3 years) were assessed for H‐ FMC reproducibility via high‐resolution ultrasound imaging of the brachial artery during and after forearm occlusion of a normal FMD procedure. Two vascular assessments were conducted for all participants during two separate visits with a minimum of 7 days in between. H‐ FMC was characterized as the greatest 10‐s average constriction occurring after 3‐s postocclusion compared to baseline brachial artery diameter and considered present if the percent change was <−0·1%. Results Of the 120 total vascular assessments performed in this study, 98 of the assessments (80·3%) displayed an H‐ FMC . H‐ FMC diameter was not statistically different for intraday comparisons for visit 1 ( P = 0·39) or visit 2 ( P = 0·55) or interday comparisons between the first ( P = 0·61) or second ( P = 0·10) assessments. H‐ FMC percentage was also not statistically different for intra‐day comparison for visit 1 ( P = 0·94) or visit 2 ( P = 0·15) or interday comparisons between the first ( P = 0·63) or second ( P = 0·16) assessments. Conclusion These data are supportive of H‐ FMC being reproducible in young adults and included in future FMD studies. The impact of H‐ FMC on future CVD risk and development warrants evaluation.