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Reference values for left ventricular systolic synchrony according to phase analysis of ECG ‐gated myocardial perfusion SPECT
Author(s) -
Hämäläinen Hanna,
Hedman Marja,
Laitinen Tiina,
Hedman Antti,
Kivelä Antti,
Laitinen Tomi
Publication year - 2018
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/cpf.12379
Subject(s) - medicine , gated spect , ventricle , cardiology , perfusion , coronary artery disease , percentile , myocardial perfusion imaging , population , ventricular dyssynchrony , ejection fraction , nuclear medicine , heart failure , cardiac resynchronization therapy , statistics , mathematics , environmental health
Summary Background The aim of this study was to define reference values for left ventricular systolic synchrony and for the volume parameters of the left ventricle using myocardial perfusion SPECT‐derived phase analysis method. Methods We evaluated data of 433 patients who underwent myocardial perfusion SPECT/CT during January 2012–February 2013 in Kuopio University Hospital. The final study population consisted of 52 patients (aged 42–84 years) who met the criteria: (1) no previously diagnosed cardiac disease, (2) normal ECG at rest, (3) no advanced coronary artery disease in CT and 4) normal myocardial perfusion in stress/rest myocardial perfusion SPECT/CT. The severity of mechanical dyssynchrony was assessed by phase analysis of gated myocardial SPECT at stress stage after pharmacological exercise and at rest using Quantitative Gated SPECT (QGS) software. Volume parameters of the left ventricle were also assessed. Results The phase histogram bandwidth at rest was 28.0 [63.7] degrees (median [95th percentile]). The standard deviation of phase histogram at rest was 7.8 [26.5] degrees. Entropy at the rest study was 54.0 [63.7] %. All left ventricular dyssynchrony parameters were statistically significantly higher at stress compared to rest. There were no statistically significant differences in dyssynchrony values between men and women. In volume parameters, reference values in male were expectedly higher than in female. Cardiac output did not differ significantly between genders. Conclusion In subjects without signs of cardiac diseases, the left ventricular systolic function is well synchronized. Phase analysis measurement does not depend on gender, age, BMI or blood pressure, but the values of dyssynchrony parameters increase during pharmacological stress.