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Semi‐quantitative myocardial perfusion measured by computed tomography in patients with refractory angina: a head‐to‐head comparison with quantitative rubidium‐82 positron emission tomography as reference
Author(s) -
Qayyum Abbas Ali,
Kühl Jørgen Tobias,
Kjaer Andreas,
Hasbak Philip,
Kofoed Klaus Fuglsang,
Kastrup Jens
Publication year - 2017
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/cpf.12322
Subject(s) - medicine , nuclear medicine , perfusion , cardiac pet , positron emission tomography , myocardial perfusion imaging , coronary artery disease , perfusion scanning , radiology
Summary Introduction Computed tomography ( CT ) is a novel method for assessment of myocardial perfusion and has not yet been compared to rubidium‐82 positron emission tomography ( PET ). We aimed to compare CT measured semi‐quantitative myocardial perfusion with absolute quantified myocardial perfusion using PET and to detect stenotic territories in patients with severe coronary artery disease. Materials and methods Eighteen patients with stenosis narrowing coronary arteries ≥70% demonstrated on invasive coronary angiography underwent rest and adenosine stress imaging obtained by 320‐multidetector CT scanner and CT / PET 64‐slice scanner. CT measured myocardial attenuation density ( AD ) and perfusion index ( PI ) were correlated to absolute PET myocardial perfusion values. Results Rest AD , rest and stress PI did not correlate to PET findings ( r = 0·412, P = 0·113; r = 0·300, P = 0·259; and r = 0·508, P = 0·064, respectively). However, there was a significant correlation between stress AD and stress PET values ( r = 0·670, P = 0·009) and between stress and rest differences for AD and PI with PET differences ( r = 0·620, P = 0·006; and r = 0·639, P = 0·004, respectively). Furthermore, significant differences were observed between remote and stenotic territories for rest and stress AD (48 ± 14 HU and 37 ± 16 HU , P = 0·002; 76 ± 19 HU and 58 ± 13 HU , P <0·001, respectively), PI (9·6 ± 2·9 and 7·5 ± 3·1, P = 0·002; 21·6 ± 4·1 and 16·9 ± 3·9, P <0·001, respectively) and PET (0·96 ± 0·37 ml g −1 min −1 and 0·86 ± 0·26 ml g −1 min −1 , P = 0·036; 2·07 ± 0·76 ml g −1 min −1 and 1·61 ± 0·76 ml g −1 min −1 , P = 0·006, respectively). Conclusions Semi‐quantitative CT parameters may be useful in the detection of myocardium subtended by stenotic coronary arteries.