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Evidence for reduced neuromuscular function in men with a history of androgen deprivation therapy for prostate cancer
Author(s) -
Girard Danielle,
Marino Frank E.,
Can Jack
Publication year - 2014
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/cpf.12084
Subject(s) - medicine , prostate cancer , androgen deprivation therapy , lean body mass , asymptomatic , body mass index , urology , endocrinology , testosterone (patch) , sarcopenia , cancer , gastroenterology , body weight
Summary Background Indices of body composition and muscular strength were compared between men with prostate cancer ( PC a) treated with androgen deprivation therapy ( ADT ) and asymptomatic matched men. Methods Nine subjects aged 63–83 years with PC a who received ADT ( PC a+ ADT ; duration 6–180 months) and 11 asymptomatic aged‐matched eugonadal men ( HM ) aged 59–80 years were assessed for prostate‐specific antigen ( PSA ) and total testosterone ( TT ). Total body non‐osseous lean mass (TBLM) and right thigh non‐osseous fat‐free mass (RTLM) were assessed using dual‐energy X‐ray absorptiometry. Peak torque of the right knee extensors at 0° s −1 ( ISO ) and 60° s −1 ( CON ), maximal handgrip strength of the dominant hand ( MHS ) and whole‐body strength ( WBS ) were assessed. ISO and CON per unit mass of RTLM and MHS and WBS per unit mass of TBLM were calculated. Results Age, height, mass, body mass index and prostate‐specific antigen were comparable between groups ( P >0·05), while TT was lower in PC a+ ADT ( P <0·01). RTLM was similar between groups ( P ≥0·075). Absolute ISO and CON were lower for PC a+ ADT ( P <0·01) as were CON per unit of RTLM and ISO per unit of RTLM ( P <0·05). Absolute MHS , WBS and MHS per unit of TBLM and WBS per unit of TBLM were lower for PC a+ ADT ( P <0·01; P <0·05). Conclusions Men with PC a who receive ADT experience significant losses in whole‐body muscular strength compared with asymptomatic age‐matched men, which may impair functional capacity. These losses in muscular strength appear to involve neuromuscular mechanisms that are yet to be identified.