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A comparison of single plasma sample methods to estimate renal clearance using 99m T c‐ethylenedicysteine and 99m T c‐mercaptoacetyltriglycine
Author(s) -
Sohaib Muhammad,
Rafique Asif,
Saeed Shabana,
Afshan Anjum
Publication year - 2013
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/cpf.12034
Subject(s) - effective renal plasma flow , medicine , nuclear medicine , renal function , plasma clearance , urology , technetium 99m , pharmacokinetics , renal blood flow , scintigraphy
Summary Several single sample methods for determination of 99m T c‐mercaptoacetyltriglycine ( MAG 3) clearance are being used clinically. Kabasakal et al . proposed a similar formula for 99m T c‐ethylenedicysteine ( EC ). This study was performed to compare his method with Bubeck et al . formula for 99m T c‐ MAG 3 already in use. Twenty‐eight subjects divided in two groups were registered which included 22 patients with various renal diseases (group‐I) and six normal volunteers (group II ). All subjects were studied twice using both the radiopharmaceuticals. The images and renogram parameters, that is T MAX and T 1/2 of both the agents, were similar in all the subjects. The clearance of the 99m Tc‐ EC was however considerably higher than 99m Tc‐ MAG 3 in both the groups (mean ± SEM =279 ± 14 ml min −1 /1·73 m 2 versus 177 ± 15 ml min −1 /1·73 m 2 in group‐I and 377 ± 11·90 ml min −1 /1·73 m 2 versus 238 ± 8·23 ml min −1 /1·73 m 2 in group II ). This difference was more pronounced in cases with reduced renal functions. Among the E ffective R enal P lasma F low ( ERPF ) values determined from EC and MAG 3 clearances in six normal volunteers, four cases only in MAG 3 had ERPF below the lower limit. This study has demonstrated superiority of single sample method for 99 m Tc‐ EC clearance over its analogous method for 99m T c‐ MAG 3.