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The echogenicity of the intima–media complex in the common carotid artery is related to insulin resistance measured by the hyperinsulinemic clamp in elderly men
Author(s) -
Lind Lars,
Wohlin Martin,
Andren Bertil,
Sundström Johan
Publication year - 2013
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/cpf.12006
Subject(s) - medicine , insulin resistance , echogenicity , cardiology , intima media thickness , common carotid artery , body mass index , insulin , population , metabolic syndrome , endocrinology , clamp , obesity , carotid arteries , surgery , ultrasonography , mechanical engineering , clamping , environmental health , engineering
Summary The echogenicity of the intima–media complex ( IM ‐ GSM ) has recently been shown to be related to the echogenicity in carotid artery plaque and to predict cardiovascular ( CV ) mortality. The present study aims to evaluate the relationship between metabolic CV risk factors, with special emphasis on insulin resistance, and IM ‐ GSM in the carotid artery. Carotid artery ultrasound with grey‐scale median analysis of the intima–media complex, IM ‐ GSM , was performed in a population sample of 480 men aged 75 years. In these subjects, a euglycemic hyperinsulinemic clamp to investigate insulin resistance was performed together with measurements of conventional CV risk factors at the age of 70. The metabolic syndrome (MetS) was defined by the NCEP / ATPIII ‐criteria. In univariate analysis, IM ‐ GSM in the common carotid artery was inversely correlated with the intima–media thickness ( IMT ), body mass index ( BMI ), waist/hip ratio, fasting glucose, serum triglycerides, low HDL cholesterol and insulin resistance at the clamp ( r = −0·24, P <0·001). In multiple regression analysis, only insulin resistance at the clamp and BMI were independently related to IM ‐ GSM . Subjects with the MetS (22%) showed a reduced IM ‐ GSM when compared to those without (64 ± 20 SD versus 68 ± 19, P <0·05). Because the echogenicity of the intima–media complex in the carotid artery is related to obesity and insulin resistance at clamp independently of IMT , this new vascular characteristic would serve as a marker of vascular alterations induced by insulin resistance and the M et S and has the advantage to be obtainable in almost all subjects.