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Dyes based on the 2(1 H )‐quinolone skeleton as potential colorimetric and fluorescent sensors for cyanide anions
Author(s) -
Kolińska Jolanta,
Grzelakowska Aleksandra,
Sokołowska Jolanta
Publication year - 2019
Publication title -
coloration technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 49
eISSN - 1478-4408
pISSN - 1472-3581
DOI - 10.1111/cote.12438
Subject(s) - cyanide , chemistry , fluorescence , acetonitrile , cytotoxicity , phosphate , nuclear chemistry , inorganic chemistry , chromatography , organic chemistry , biochemistry , physics , quantum mechanics , in vitro
The sensing properties of dyes based on 2(1 H ) quinolones containing dicyanoethylene groups towards selected anions such as CN − , F − , I − , Cl − , SCN − , CH 3 COO − , NO 2 - and ClO 4 - were evaluated. The spectroscopic responses of these compounds were investigated in a solution of acetonitrile/water (1:9, v/v) and phosphate buffer at a pH of 7.4. These dyes were found to act as efficient colorimetric and high turn–off fluorescent sensors to cyanide anions. The fluorescence intensity was linearly related to the concentration of CN − from 1 to 10 µmol/L, and the detection limits reached a micromolar level of 6.7, 11.1, 3.8 and 7.2 µmol/L for 1‐4 , respectively. The cytotoxic effect of the dyes against human neuroblastoma cells (SH‐SY5Y) was also determined by MTT assay. The examined compounds exhibited slight cytotoxicity against cells under experimental conditions.