Premium
The synthesis and spectroscopic characterisation of 3‐formyl‐2‐quinolones in the presence of biothiols
Author(s) -
Grzelakowska Aleksandra,
Kolińska Jolanta,
Mąkiewicz Mariusz
Publication year - 2018
Publication title -
coloration technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 49
eISSN - 1478-4408
pISSN - 1472-3581
DOI - 10.1111/cote.12355
Subject(s) - chemistry , cysteine , amino acid , fluorescence , selectivity , thiol , singlet state , absorption (acoustics) , singlet oxygen , photochemistry , organic chemistry , biochemistry , oxygen , materials science , physics , composite material , quantum mechanics , nuclear physics , excited state , enzyme , catalysis
The derivatives of 3‐formyl‐2(1 H )‐quinolones and N‐methyl‐3‐formyl‐2‐quinolones substituted in the 6‐position with either a methyl or a methoxy group were synthesised and evaluated as potential sensors for the detection of thiol amino acids. Their spectroscopic properties, including absorption and emission spectra, fluorescence quantum yields and singlet lifetimes, were examined. The behaviour of the obtained compounds was studied at pH 7.4 in the presence of various amino acids. The results show that these compounds demonstrate a high turn‐off fluorescence response and selectivity toward L‐cysteine in the presence of other amino acids, and have the potential to act as sensors to L‐cysteine.