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Long‐term gastrointestinal sequelae in colon cancer survivors: prospective pilot study on identification, the need for clinical evaluation and effects of treatment
Author(s) -
Larsen Helene M.,
Mekhael Mira,
Juul Therese,
Borre Mette,
Christensen Peter,
Mohr Drewes Asbjørn,
ThorlaciusUssing Ole,
Laurberg Søren,
Krogh Klaus,
Ladefoged Fassov Janne
Publication year - 2021
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.15544
Subject(s) - medicine , quality of life (healthcare) , colorectal cancer , cancer , gastrointestinal cancer , cohort , prospective cohort study , clinical trial , cohort study , stage (stratigraphy) , clinical endpoint , gastroenterology , surgery , nursing , biology , paleontology
Aim The aim of the present pilot study was to describe the type and frequency of long‐term gastrointestinal symptoms within a well‐defined cohort of colon cancer survivors, their wish for clinical evaluation and treatment outcomes. Method A screening survey was sent to colon cancer survivors 12, 24 and 36 months after surgery. Based on their main symptoms, patients who wished to have a consultation were referred to the gastroenterological or surgical unit of our late cancer sequelae clinic. Treatment effect was monitored by questionnaires on bowel symptoms and the EuroQol five‐dimensional (EQ‐5D) quality‐of‐life score. Results Overall, 953 patients who had survived colon cancer received the screening survey and 767 replied (response rate 80.5%). Of these, 76 (9.9%; 95% CI 7.9%–12.2%) were referred for algorithm‐based clinical evaluation and treatment of bowel dysfunction. The majority were women (69.7%) who had undergone a right‐sided colonic resection (65.8%). Patients reported various symptoms, mainly including urgency, fragmented defaecation, loose stools and incontinence for liquid stools. Patients with emptying difficulties and low anterior resection syndrome‐like symptoms were referred to the surgical unit and patients with diarrhoea were referred to the gastroenterological unit for clinical work‐up. Our main endpoint, mean EQ‐5D index after treatment, was improved compared with baseline (baseline 0.809, after treatment 0.846; p = 0.049). After treatment, self‐rated bowel function and several bowel symptoms were improved as well. Conclusion This study highlights the importance of identifying colon cancer survivors in need of treatment of late gastrointestinal sequelae and clinical management in a multidisciplinary team setting.