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Association of low skeletal muscle mass with the presence of advanced colorectal neoplasm: integrative analysis using three skeletal muscle mass indices
Author(s) -
Lee H. J.,
Lee J. Y.,
Lee M. J.,
Kim H.K.,
Kim N.,
Kim G.U.,
Lee J.S.,
Park H. W.,
Chang H.S.,
Yang D.H.,
Choe J.,
Byeon J.S.
Publication year - 2020
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.15103
Subject(s) - medicine , quartile , body mass index , bioelectrical impedance analysis , odds ratio , skeletal muscle , population , confidence interval , environmental health
Aim This study aimed to evaluate an association between colorectal neoplasm (CRN) and skeletal muscle mass using three widely accepted skeletal muscle mass indices (SMIs) in a large population at average risk. Method We performed a cross‐sectional study using a screening colonoscopy database of 33 958 asymptomatic subjects aged 40–75 years. Appendicular skeletal muscle mass (ASM) was measured using a bioelectrical impedance analyser. ASM adjusted for height squared (ASM/ht 2 ), weight (ASM/wt) and body mass index (ASM/BMI) were used as indices for muscle mass. Logistic regression models were used to evaluate the association between SMIs and CRN. Results In a multivariable‐adjusted model, the risk of an advanced CRN increased linearly with decreasing quartiles for all three SMIs. The adjusted odds ratios (ORs) for advanced CRN in quartiles 1, 2 and 3 of ASM/wt compared with that in quartile 4 were 1.279, 1.196 and 1.179, respectively ( P trend = 0.017); for ASM/BMI, ORs were 1.307, 1.144 and 1.091, respectively ( P trend = 0.002); and for ASM/ht 2 , ORs were 1.342, 1.169 and 1.062, respectively ( P trend = 0.002). The risk of distally located advanced CRN was higher in quartile 1 than in quartile 4 for all three SMIs (ASM/wt, OR = 1.356; ASM/BMI, OR = 1.383; ASM/ht 2 , OR = 1.430). Conclusion Our study demonstrated that low skeletal muscle mass was consistently associated with the presence of advanced CRN in a population at average risk regardless of the operational definition of the SMI, and it was particularly associated with distal advanced CRN.