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Effect of activated carbon nanoparticles on lymph node harvest in patients with colorectal cancer
Author(s) -
Tang L.,
Sun L.,
Zhao P.,
Kong D.
Publication year - 2019
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.14538
Subject(s) - medicine , carbon nanoparticles , colorectal cancer , lymph node , activated carbon , lymph , oncology , nanoparticle , general surgery , cancer , pathology , chemical engineering , chemistry , organic chemistry , adsorption , engineering
Aim The aim was to examine the effect of activated carbon nanoparticles ( ACN s) on lymph node retrieval in colorectal cancer ( CRC ) patients. Methods This prospective randomized study of 80 subjects was performed between March 2016 and December 2016. Eighty patients with CRC were randomly divided into two groups, the ACN group and a control group. The patients in the ACN group were subjected to 1 ml of ACN injection in the subserosa around the tumour before colectomy and D3 lymphadenectomy. The patients in the control group received the same procedure without the injection of ACN s. After surgery, lymph nodes were isolated, and the greatest dimensions were measured by the same pathologist. Results The average number of lymph nodes harvested from each patient was markedly more in the ACN group (31.3 ± 8.1) than in the control group (21.9 ± 5.3; P < 0.001), and the average number of lymph nodes less than 5 mm in greatest dimension was significantly more in the ACN group (11.9 ± 4.9) than in the control group (4.1 ± 2.4; P < 0.001). The ACN group (15/40) had a higher rate of Stage III patients compared to the control group (6/39; P = 0.026). Besides, the greatest dimension of 32.8% metastatic lymph nodes was less than 5 mm. Conclusion There is significant upstaging following the use of ACN s, which could find more involved nodes. Therefore, ACN s can be used as a tracer to harvest more lymph nodes in CRC patients, with improvement in the accuracy of pathological staging.