Premium
Human papillomavirus infection and colorectal cancer in the Chinese population: a meta‐analysis
Author(s) -
Zhang X.h.,
Wang W.,
Wang Y.q.,
Jia D.f.,
Zhu L.
Publication year - 2018
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.14416
Subject(s) - medicine , colorectal cancer , human papillomavirus , meta analysis , oncology , population , cervical cancer , medline , papillomaviridae , china , cancer , virology , environmental health , political science , law
Aim Human papillomavirus ( HPV ) infection has been reported in colorectal cancer in many studies. We conducted a meta‐analysis to assess the association between HPV infection and colorectal cancer/adenomas in the Chinese population. Method Relevant studies up to January 2018 were searched in PubMed, EMBASE , China National Knowledge Infrastructure and the Wanfang database. We used a random effects model to determine the prevalence of HPV and odds ratios ( OR s) with 95% confidence intervals ( CI s). The I 2 statistic and P ‐value from the Cochrane Q ‐test were used to describe the heterogeneity. Results Ten case–control studies involving 766 colorectal cancer patients and 470 controls were included in the meta‐analysis. Among the colorectal cancer patients, the pooled prevalence was 0.45 (95% CI 0.36–0.53). The pooled estimate for OR was 10.78 (95% CI 4.22, 27.53). Among the 193 patients with colorectal adenoma, the pooled prevalence and OR were 0.31 (95% CI 0.24–0.37) and 2.03 (95% CI 0.79, 5.26), respectively. The prevalence of HPV 16 and HPV 18 among HPV ‐positive cancers ranged from 57.9% to 100% and 0% to 39.7%, respectively. Conclusion The results indicated that HPV infection, especially HPV 16 and HPV 18, is associated with colorectal cancer in the Chinese population.