Premium
The relationship between 18 F‐ FDG ‐ PETCT ‐derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer
Author(s) -
McSorley S. T.,
Khor B. Y.,
Tsang K.,
Colville D.,
Han S.,
Horgan P. G.,
McMillan D. C.
Publication year - 2018
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.13973
Subject(s) - medicine , colorectal cancer , systemic inflammation , inflammation , positron emission tomography , gastroenterology , neutrophil to lymphocyte ratio , standardized uptake value , fluorodeoxyglucose , cancer , nuclear medicine , oncology , lymphocyte
Aim 18 F‐fluorodeoxyglucose positron emission tomography‐computed tomography ( 18 F‐ FDG ‐ PETCT )‐derived markers of tumour metabolism have been reported to have prognostic significance in a variety of tumours. Host inflammation is also recognized to have prognostic significance. The aim of the present study was to investigate the relationship between these markers and host systemic inflammation in patients undergoing elective surgery for colorectal cancer. Method Patients with histologically confirmed colorectal cancer who underwent elective surgery between 2008 and 2015 and also underwent 18 F‐ FDG ‐ PETCT at a single centre were included ( n = 103). The neutrophil–lymphocyte ratio ( NLR ) and modified Glasgow Prognostic Score ( mGPS ) were derived from routine blood tests. The maximum standardized uptake ( SUV max), peak standardized uptake ( SUV peak), metabolic tumour volume ( MTV ) and total lesion glycolysis ( TLG ) were measured. Results There was no association between 18 F‐ FDG ‐ PETCT measures of tumour metabolism and systemic inflammation in the 33 patients who underwent preoperative imaging. Of the 70 patients with recurrent disease who underwent 18 F‐ FDG ‐ PETCT during follow‐up, patients with NLR ≥ 5 had a significantly higher SUV max (20 vs 7, P = 0.002), SUV peak (14 vs 5, P < 0.001), MTV (29 g vs 2 g, P = 0.001) and TLG (338 g vs 9 g, P < 0.001). Similarly, patients with a mGPS of 1–2 at the time of 18 F‐ FDG ‐ PETCT had a significantly higher median SUV max (11 vs 6, P = 0.048), SUV peak (8 vs 4, P = 0.046), MTV (13 ml vs 2 ml, P = 0.005) and TLG (146 g vs 10 g, P = 0.004). Conclusion The present study reports a direct association between 18 F‐ FDG ‐ PETCT ‐derived measures of tumour metabolism and systemic inflammation in patients with recurrent colorectal cancer.