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Circumferential margin involvement after total mesorectal excision for mid or low rectal cancer: are all R1 resections equal?
Author(s) -
Beaufrère A.,
Guedj N.,
Maggiori L.,
Patroni A.,
Bedossa P.,
Panis Y.
Publication year - 2017
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.13895
Subject(s) - medicine , total mesorectal excision , colorectal cancer , proportional hazards model , group b , multivariate analysis , gastroenterology , group a , prospective cohort study , surgery , cancer
Aim Our aim was to assess the prognostic influence of the circumferential resection margin ( CRM ) exact value after total mesorectal excision for mid or low rectal cancer. Methods All patients ( n = 321) who underwent total mesorectal excision from 2005 to 2013 were identified from a prospective database, including 49 (15%) who presented with a CRM ≤ 1 mm. Four groups were defined: group 1, CRM = 0 mm ( n = 21); group 2, 0 < CRM ≤ 0.4 mm ( n = 13); group 3, 0.4 < CRM ≤ 1 mm ( n = 15); group 4, CRM > 1 mm ( n = 272). Results After a mean follow‐up of 42 ± 26 months, locoregional recurrence rates were 8/21 (38%) in group 1, 3/13 (23%) in group 2, 0/12 (0%) in group 3 and 26/272 (10%) in group 4 ( P < 0.001), leading to significantly impaired 3‐year locoregional recurrence‐free survival in group 1 (57% ± 13%) and group 2 (56% ± 15%) compared to group 3 (85% ± 10%, vs group 1, P = 0.021, vs group 2, P = 0.049) and to group 4 (89% ± 2%, vs group 1, P < 0.001, vs group 2, P < 0.001). In multivariate Cox analysis, a CRM ≤ 0.4 mm was identified as an independent factor impairing both locoregional recurrence‐free survival ( OR 3.14, 95% CI 1.53–6.46; P = 0.002) and disease‐free survival ( OR 2.15, 95% CI 1.28–3.63; P = 0.004). Conclusion Our study suggests that the prognosis after mid or low rectal cancer surgery was worse with a CRM ≤ 0.4 mm. The prognosis was similar in patients with a CRM > 0.4 mm or ≤ 1 mm and patients with an R0 resection.