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Is the interval from surgery to ileostomy closure a risk factor for low anterior resection syndrome?
Author(s) -
JiménezRodríguez R. M.,
SeguraSampedro J. J.,
RiveroBelenchón I.,
Díaz Pavón J. M.,
García Cabrera A. M.,
Vazquez Monchul J. M.,
Padillo J.,
Portilla F.
Publication year - 2017
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.13524
Subject(s) - medicine , ileostomy , closure (psychology) , surgery , resection , risk factor , general surgery , market economy , economics
Aim Low anterior resection syndrome ( LARS ) comprises a collection of symptoms affecting patients after restorative surgery for rectal cancer. The aim of the present study was to analyse the incidence of LARS in patients undergoing rectal cancer surgery with and without subsequent ileostomy and to determine whether the interval to ileostomy closure is a factor associated with its occurrence. Method All patients undergoing curative anterior resection for rectal cancer from 2008 to 2012 in our institution were included in the study. They were divided into two groups according to whether or not a defunctioning ileostomy had been performed. Patients were assessed for LARS at a median interval of 23.60 ± 16.73 (12−48) months from anterior resection in those who did not have an ileostomy and at an interval of 11.31 ± 14.24 (12−60) months from closure of the ileostomy in those who did. They underwent a structured telephone interview based on a validated LARS score questionnaire. Univariate and multivariate analysis was carried out to assess possible associations between LARS and the variables studied. Results There were 150 patients (93 men) of whom 54.7% had no evidence of LARS , 17.3% had minor symptoms and 28% major symptoms of LARS . Univariate analysis showed that male gender, the presence of a temporary ileostomy and neoadjuvant therapy were predisposing factors for LARS . The interval from construction of the ileostomy to its closure did not appear to be a factor associated with LARS . In multivariate analysis, male gender and preoperative neoadjuvant therapy were significant predisposing factors for LARS . Conclusion Male gender and preoperative neoadjuvant therapy are risk factors for LARS . The presence of ileostomy or time to ileostomy closure is not associated with the development of this syndrome.