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The accuracy of circulating micro RNA ‐21 in the diagnosis of colorectal cancer: a systematic review and meta‐analysis
Author(s) -
Xu F.,
Xu L.,
Wang M.,
An G.,
Feng G.
Publication year - 2015
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.12917
Subject(s) - medicine , diagnostic odds ratio , meta analysis , likelihood ratios in diagnostic testing , cochrane library , confidence interval , odds ratio , colorectal cancer , receiver operating characteristic , biomarker , medline , oncology , publication bias , cancer , biochemistry , chemistry , political science , law
Aim The accuracy and clinical value of circulating micro RNA ‐21 (miR‐21) were assessed as a novel diagnostic biomarker of colorectal cancer ( CRC ). Method Medline/PubMed, EMBASE , the Cochrane Library databases and grey literature (Google scholar; British Library) were searched up to 29 September 2014 for eligible studies of the association between blood‐based miR‐21 and a diagnosis of CRC . Quality Assessment of Diagnostic Accuracy Studies ( QUADAS ) was employed to assess the quality of the included studies by two investigators. Stata12.0 and Meta‐DiSc1.4 software were applied to test the heterogeneity using Cochran's Q test and I 2 statistics and to perform the meta‐analysis. Results Seven studies with 676 CRC patients and 417 controls were included in the meta‐analysis. All were of high quality ( QUADAS scores 12 or 13). For miR‐21, the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio to predict CRC were 75% [95% confidence interval ( CI ) 63–83%], 84% (95% CI 79–87%), 4.61 (95% CI 3.38–6.29), 0.30 (95% CI 0.20–0.46) and 16.89 (95% CI 7.56–37.73) after using a random‐effects model analysis. The area under the summary receiver operating characteristic curve was 0.86 (95% CI 0.83–0.89). Conclusion The results suggest that circulating miR‐21 is a biomarker with moderate sensitivity and specificity for CRC .