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Streptococcus bovis infection and colorectal neoplasia: a meta‐analysis
Author(s) -
Krishnan S.,
Eslick G. D.
Publication year - 2014
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.12662
Subject(s) - streptococcus bovis , medicine , meta analysis , endocarditis , incidence (geometry) , carriage , study heterogeneity , feces , gastroenterology , microbiology and biotechnology , pathology , biology , rumen , physics , food science , fermentation , optics
Aim A meta‐analysis was conducted to determine the risk associated with Streptococcus bovis infection and the occurrence of colorectal neoplasia ( CRN ). The level of risk remains unknown. Method We conducted a search of MEDLINE , PubMed and EMBASE up to January 2014. We used a random‐effects model to analyse the data. Results We identified 48 studies concerning three main topics: S. bovis septicaemia, S. bovis endocarditis and S. bovis faecal carriage. The total sample sizes were 1729, 807 and 1145, respectively; the 48 studies included 9 case–control studies and 39 case series. Overall, the presence of S. bovis infection was found to be significantly associated with the presence of CRN . Streptococcus bovis endocarditis showed the strongest association in analyses of case–control studies and case series ( OR 14.54, 95% CI 5.66–37.35, test for heterogeneity I 2 = 43.53; event rate of 0.53, 95% CI 0.45–0.61, test for heterogeneity I 2 = 53.50). Similarly, S. bovis septicaemia was also associated with a high level of concurrence with CRN ( OR 7.48, 95% CI 3.10–18.06 , test for heterogeneity I 2 = 43.32; event rate 0.49, 95% CI 0.42–0.56, test for heterogeneity I 2 = 69.97). Patients with CRN were found to have a higher incidence of S. bovis in faeces upon stool culture ( OR 2.52, 95% CI 1.14–5.58, test for heterogeneity I 2 = 69.17). Conclusion The meta‐analysis showed a statistically significant association between the presence of S. bovis endocarditis or S. bovis septicaemia and CRN . Furthermore, there is a statistically significant increase in likelihood of finding S. bovis in the stool of individuals with CRN .