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Association between H elicobacter pylori infection and the risk of colorectal neoplasia: a systematic review and meta‐analysis
Author(s) -
Wu Q.,
Yang Z.P.,
Xu P.,
Gao L.C.,
Fan D.M.
Publication year - 2013
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.12284
Subject(s) - medicine , meta analysis , odds ratio , colorectal adenoma , colorectal cancer , confidence interval , subgroup analysis , gastroenterology , relative risk , oncology , cancer
Aim The existing evidence on the relationship between H elicobacter pylori infection and the risk of colorectal neoplasia is inconsistent. We conducted a systematic review with a meta‐analysis to explore this relationship and to determine whether the relationship varies according to the study characteristics. Method We searched the P ub M ed database and the reference lists of pertinent articles published up to July 2012. Summary odds ratios ( OR s) with their 95% confidence intervals ( CI s) were estimated using a random‐effects model. Results Twenty‐seven studies including 3792 cases of colorectal adenoma ( CRA ) and 3488 cases of colorectal cancer ( CRC ) were identified. Overall, H . pylori infection was associated with an increased risk of CRA ( OR = 1.66, 95% CI 1.39–1.97, I 2 = 54.3%) and CRC ( OR = 1.39, 95% CI 1.18–1.64, I 2 = 35.8%), although there was significant heterogeneity among the studies. Subgroup analysis revealed that the positive correlation did not differ by sex, geographic variation or subsite of neoplasia, but might vary by the method of detection of H . pylori . The study was underpowered to determine the risk of colorectal neoplasia associated with cytotoxin‐associated gene A ‐positive H . pylori . Conclusion This meta‐analysis demonstrates a positive association between H . pylori infection and the risk of colorectal neoplasia.