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Tumour diameter is a predictor of mesorectal and mesenteric lymph node metastases in anorectal melanoma
Author(s) -
Wang M.,
Zhang Z.,
Zhu J.,
Sheng W.,
Lian P.,
Liu F.,
Cai S.,
Xu Y.
Publication year - 2013
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.12250
Subject(s) - medicine , perineural invasion , lymph node , melanoma , hazard ratio , total mesorectal excision , lymph , colorectal cancer , radiology , surgery , cancer , pathology , confidence interval , cancer research
Aim Anorectal melanoma is a rare neoplasm with poor prognosis. The aim of this study was to investigate what clinicopathological factors predict lymph node metastases and to investigate their association with survival. Method Patients undergoing surgery with curative intent for primary anorectal melanoma in F udan U niversity S hanghai C ancer C enter between 1989 and 2011 were studied retrospectively. The associations between clinicopathological factors and lymph node metastases and prognosis were determined. Results Forty‐three patients underwent a potentially curative resection with a median follow‐up of 20 months; the 5‐year overall survival rate was 29.6% with median overall survival of 28 months. Tumour diameter > 3 cm was associated with mesorectal and mesenteric lymph node metastases ( P = 0.013). Perineural invasion (hazard ratio 5.683; 95% CI 1.978–16.328; P = 0.001) was the only factor that independently predicted survival. Conclusion Tumour diameter was associated with mesorectal and mesenteric lymph node metastases; therefore, wide local excision may not be appropriate for surgery with curative intent for patients with a tumour diameter ≥ 3 cm. Perineural invasion was an important prognostic factor for anorectal melanoma.