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Prognostic and diagnostic significance of annexin A2 in colorectal cancer
Author(s) -
Yang T.,
Peng H.,
Wang J.,
Yang J.,
Nice E. C.,
Xie K.,
Huang C.
Publication year - 2013
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.12207
Subject(s) - medicine , proportional hazards model , receiver operating characteristic , hazard ratio , colorectal cancer , oncology , survival analysis , stage (stratigraphy) , immunohistochemistry , gastroenterology , lymph node , cancer , pathology , confidence interval , paleontology , biology
Aim Annexin A 2 ( ANXA 2) is known to be a tumourigenic molecule and is highly expressed in colorectal cancer ( CRC ). Its diagnostic and prognostic value is not fully understood. This study was designed to investigate the relationship between ANXA 2 expression, clinicopathological characteristics, tumour recurrence and survival. Method Immunohistochemical staining was used to evaluate ANXA 2 expression in 150 matched samples from patients with CRC . Overall survival and recurrence were determined by Kaplan–Meier analysis. The Cox proportional hazards model was used to determine independent factors contributing to survival and recurrence. Receiver operating characteristic ( ROC ) curve and liner correlation analysis were used to estimate the sensitivity and specificity of ANXA 2 expression for clinical diagnosis. Results ANXA 2 was found to be strongly expressed in poorly differentiated tumours ( P < 0.001), late stage ( P = 0.020) and lymph node positivity ( P = 0.002). ANXA 2 expression was significantly related to recurrence ( P < 0.001) and survival ( P = 0.002). The Cox proportional hazards model indicated that ANXA 2 expression [ P < 0.001, hazard ratio ( HR ) = 1.366, 95% CI 1.232–1.515] and tumour location ( P = 0.039, HR = 1.891, 95% CI 1.034–3.456) were independent factors in predicting overall survival while ANXA 2 expression ( P < 0.001, HR = 1.445, 95% CI 1.222–1.709) were independent factors predicting recurrence. Receiver operating characteristic ( ROC ) ( AUC = 0.768, 95% CI = 0.642–0.894) and liner correlation analysis suggested that ANXA 2 was suitable for the clinical diagnosis of CRC . Conclusion These results indicate that ANXA 2 is a biomarker with diagnostic and prognostic potential for patients with CRC .