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Survival of patients with S tage III colon cancer is improved in hereditary non‐polyposis colorectal cancer compared with sporadic cases. A D anish registry based study
Author(s) -
Brixen L. M.,
Bernstein I. T.,
Bülow S.,
Ehrnrooth E.
Publication year - 2013
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/codi.12150
Subject(s) - medicine , colorectal cancer , gastroenterology , stage (stratigraphy) , cancer , family history , oncology , paleontology , biology
Aim Patients with hereditary non‐polyposis colorectal cancer ( HNPCC ) seem to have a better prognosis than those with sporadic colorectal cancer ( CRC ). The aim was to compare survival after Stage III CC in patients with HNPCC with those having sporadic CC . Method A total of 230 patients with hereditary cancer from the D anish HNPCC Register and 3557 patients with sporadic CC from the D anish C olorectal C ancer D atabase, diagnosed during M ay 2001– D ecember 2008, were included. HNPCC patients were classified according to mismatch repair mutation status and family pedigree. Sporadic cases had no known family history of cancer. Patient characteristics, geographical differences and survival data were analysed. Results The overall survival ( OS ) was better in HNPCC patients compared with sporadic CC after stratification for sex and age ( P = 0.02; CI 1.04–1.7). The 5‐year survival was 70% in HNPCC patients compared with 56% in sporadic CC ( P < 0.001). No survival difference was found between HNPCC subgroups but a tendency to better OS was seen in patients with L ynch syndrome. No geographical differences in OS were found. The median follow‐up was 3.9 (0–9.5) years for HNPCC vs 3.2 (0–9.6) years for sporadic CC . Conclusion HNPCC patients with Stage III CC have a better OS compared with sporadic CC . No significant difference in OS was found within HNPCC subgroups.