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Multicenter 1‐month follow‐up study of the patch test reaction to the gold sodium thiosulfate of the TRUE Test and its association with piercings and dental metal history
Author(s) -
Suzuki Kayoko,
Matsunaga Kayoko,
Ito Akiko,
Yagami Akiko,
Ito Takashi,
Miyazawa Hitoshi,
Sugiura Mariko,
Adachi Atsuko,
Kubota Yumiko,
Watanabe Yuko,
Kato Atsuko,
Nishioka Kazue,
Fukunaga Atsushi,
Mochizuki Masako,
Ikezawa Yuko,
Tsunoda Takahiko,
Takayama Kaoru,
Washizaki Kumiko,
Yokozeki Hiroo,
Ishihara Takuma,
Asada Hideo,
Kanto Hiromi
Publication year - 2021
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.13827
Subject(s) - patch test , sensitization , gold standard (test) , dentistry , medicine , sodium thiosulfate , chemistry , inorganic chemistry , immunology , allergy
Abstract Background There is controversy over late and long‐lasting reactions to gold sodium thiosulfate (GST). Objectives To study the GST patch test reaction by observing the application site after 1 month, and to clarify the relevance of GST sensitization by piercings and dental metals. Patients A retrospective analysis was performed on 746 patients (143 male; 603 female) who were patch tested using GST of the TRUE Test. We conducted a questionnaire on the presence of piercings or dental metals in these patients. Results The GST positive rate was 27.9% at day (D)3 and/or D7 and 40.3% up to the 1‐month reading. The positive rate was significantly higher in female patients and increased with age. Sixty‐two percent of cases with a positive reaction at D7 continued to show a positive reaction after 1 month. Eleven percent of cases with a negative reaction at D3 and D7 showed a late reaction. Both piercings and dental metals were related to gold sensitization. Conclusions The GST of the TRUE Test had a high positive and low false‐negative rate. The 1‐month reading after the patch test was important for identifying late reactions. Piercing history and dental metal were associated with gold sensitization.