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Concomitant positive patch test reactions in FreeStyle‐allergic patients sensitized to isobornyl acrylate
Author(s) -
Dendooven Ella,
Foubert Kenn,
Goossens An,
Gilles Philippe,
De Borggraeve Wim,
Pieters Luc,
Lambert Julien,
Aerts Olivier
Publication year - 2021
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.13706
Subject(s) - patch test , concomitant , sesquiterpene , allergic contact dermatitis , acrylate , allergy , contact dermatitis , chemistry , medicine , dermatology , patch testing , organic chemistry , surgery , immunology , copolymer , polymer
Abstract Background Concomitant positive patch test reactions in patients sensitized to isobornyl acrylate (IBOA) have rarely been documented. Objectives To report concomitant sensitizations in patients with allergic contact dermatitis (ACD) from the glucose sensor FreeStyle Libre and sensitized to IBOA. Methods In 2019, 26 patients with suspected ACD from FreeStyle Libre were patch tested to a baseline series and to a (meth) acrylate series containing IBOA and 2‐phenoxyethyl acrylate (PEA) 0.1% pet. Diabetes devices and patch test preparations were analyzed with gas chromatography – mass spectrometry (GC‐MS) for the presence of IBOA and PEA. Results Of the 26 patients, 18 (69%) were sensitized to IBOA, and eight (44%) and 11 (61%) of these were co‐sensitized to sesquiterpene lactones and fragrances, respectively. Ten patients (56%) were co‐sensitized to PEA, which, contrary to IBOA, could not be detected in any device. The PEA test material was shown to be contaminated with IBOA. Conclusions Contact allergy to IBOA appears to be declining and IBOA‐sensitized patients are most often co‐sensitized to sesquiterpene lactones and fragrances. Vigilance is required when patch testing (acrylate) materials obtained from industry, as these might be contaminated and, hence, alter the results and their interpretation.