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Patch testing with a textile dye mix with and without Disperse Orange 3
Author(s) -
Stenton Joanna,
Dahlin Jakob,
Antelmi Annarita,
Bruze Magnus,
Svedman Cecilia,
Zimerson Erik,
Hamnerius Nils,
Pontén Ann,
Isaksson Marléne
Publication year - 2020
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.13660
Subject(s) - medicine , patch test , dermatology , allergen , allergic contact dermatitis , orange (colour) , allergy , contact allergy , patch testing , contact dermatitis , immunology , chemistry , food science
Background The textile dye mix (TDM) 6.6% pet. contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM‐positive patients is DO 3. Around 85% of p ‐phenylenediamine (PPD)‐allergic dermatitis patients have shown positive patch test reactions to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of frequent, strong reactions to TDM 6.6% and PPD. Objectives To study if DO 3 can be omitted from a TDM. Methods Patch tests were performed on 2250 dermatitis patients with TDM 6.6%, TDM 5.6% pet., TDM 7.0% pet., and PPD 1.0% pet.; 122 patients were also patch tested with DO 3 1.0% pet. Results Among the 2250 patients patch tested, contact allergy prevalence to TDM 6.6% was 2.4%, to TDM 5.6% 1.8%, and to TDM 7.0% 2.0%. Of the 54 TDM 6.6%‐positive patients, 55.6% reacted to PPD; as much as 42.2% of PPD‐allergic women and 50% of PPD‐allergic men reacted to TDM 6.6%. Of the 17 DO 3‐positive patients, 94.1% showed a positive reaction to PPD. Conclusion Results indicate that DO 3 can probably be omitted from TDM, but patch testing with TDM 6.6%, TDM 7.0%, DO 3 1.0%, and PPD 1.0% simultaneously is needed to finally decide whether it is possible or not.