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Skin application of glutathione and iron sulfate can inhibit elicitation of allergic contact dermatitis from hexavalent chromium
Author(s) -
Lejding Tina,
Engfeldt Malin,
Bruze Magnus,
Isaksson Marléne,
Svedman Cecilia,
Zimerson Erik,
Verma Kaushal,
Mowitz Martin
Publication year - 2020
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.13409
Subject(s) - potassium dichromate , hexavalent chromium , allergic contact dermatitis , chemistry , patch test , chromium , contact allergy , contact dermatitis , glutathione , sulfate , allergy , cosmetics , nuclear chemistry , dermatology , medicine , immunology , inorganic chemistry , organic chemistry , enzyme
Background Allergic contact dermatitis (ACD) caused by hexavalent chromium, Cr(VI), is often severe and difficult to treat. The most common source of exposure to Cr(VI) in Sweden used to be cement, and more recently leather. The contact allergy can be diminished or inhibited if the exposure is decreased or ceases. Barrier creams against different kinds of allergens have been investigated for their protective properties which may offer protection against Cr(VI) exposure. Objectives To investigate the capacity of formulas containing glutathione (GSH) and iron sulfate to inhibit elicitation of ACD in Cr(VI)‐allergic individuals when exposed to Cr(VI). Methods In 18 Cr(VI)‐allergic volunteers the back was divided into eight patch test areas which were treated with preparations of possible barrier creams, prior to patch testing with a dilution series of potassium dichromate and a buffered extract of cement. Results A significant reduction in reactivity to Cr(VI) and cement extract on skin treated with formulas containing GSH or iron sulfate was noticed, compared with untreated skin. Conclusion Formulas containing GSH or iron sulfate in barrier creams inhibit ACD in individuals allergic to Cr(VI) when applied before exposure to Cr(VI) and cement extract.