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Barrier damaging effects of n ‐propanol in occlusion‐modified tandem repeated irritation test: Modulation by exposure factors and atopic skin disease
Author(s) -
AngelovaFischer Irena,
Soltanipoor Maryam,
Stilla Tasja,
Fischer Tobias W.,
Kezic Sanja,
Jakasa Ivone
Publication year - 2020
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/cod.13368
Subject(s) - transepidermal water loss , irritation , atopic dermatitis , medicine , erythema , dermatology , immunology , pathology , stratum corneum
Abstract Background Recent studies provide evidence for significant and previously underestimated barrier damaging effects of repeated exposure to 60% n ‐propanol in healthy skin in vivo . Objectives To investigate further the cumulative effects of a range of n ‐propanol concentrations relevant at the workplace in healthy and atopic dermatitis (AD) individuals, and study the modulation of the outcomes by co‐exposure and host‐related factors. Methods Healthy adult and AD volunteers were exposed to n ‐propanol concentrations from 30% to 75% in occlusion‐modified tandem repeated irritation test with measurements of erythema, transepidermal water loss, capacitance, and the natural moisturizing factor (NMF) levels at baseline and after 96 hours. Results n ‐Propanol exerted significant barrier damaging effects even at the lowest concentration in both groups. Exposure to all n ‐propanol concentrations significantly reduced the NMF levels. Preceding low‐grade trauma by occlusion/water exposure reduced the skin irritation threshold in both groups. The differences in the severity of the barrier function impairment after exposure to the same concentrations under the same conditions between the AD and control groups were significant. Conclusions The negative effects of cumulative exposure to n ‐propanol in healthy and atopic skin shown in the study suggest the need for critical re‐evaluation of its irritant properties in vivo .